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In accordance with REACH regulations, before conducting tests under Annex IX and X (for registration volumes of 100-1000 tons per year and over 1000 tons per year), registrants must submit a testing proposal (TP). After a consultation period, ECHA will finalize the testing requirements based on feedback and the characteristics of the substance.

On May 14, 2024, the European Chemicals Agency (ECHA) announced 12 new substance testing proposals and invited the public to submit their comments by following dates.

ECHA’s public consultation on substance testing proposals is a transparent process to determine if additional testing is needed for chemical registration dossiers to ensure safety. This process gathers input from various stakeholders to improve chemical safety assessments. After the consultation period, ECHA will adjust the testing requirements based on the feedback. Registrants must then conduct the specified tests, submit the results, and update their safety documentation to ensure safe use and promote industry sustainability.

Name	EC Num./ CAS Num.	Hazard endpoint for which vertebrate testing was proposed	Deadline for submitting information
4,4'-methylenebis[N,N-bis(2,3-epoxypropyl)aniline]	249-204-3 28768-32-3	6.1.2 Long-term toxicity to fish	27/05/2024
Dibromomethane	200-824-2 74-95-3	7.6.2 Genetic toxicity in vivo	27/05/2024
Diethyl succinate	204-612-0 123-25-1	7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity	27/05/2024
Manganate(1-), glycinato-N,O)[sulfato(2-)-O]-, hydrogen	838-538-0 52139-31-8	7.6.2 Genetic toxicity in vivo	27/05/2024
Menthol	201-939-0 89-78-1	6.1.2 Long-term toxicity to fish	28/06/2024
N,N-dimethylacrylamide	220-237-5 2680-03-7	7.8.2 Developmental toxicity / teratogenicity	28/06/2024
N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine	470-720-1 189253-72-3	7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity	27/05/2024
N-[3-(dimethylamino)propyl] C6-9 alkyl amides	948-134-7 -	6.1.2 Long-term toxicity to fish	28/06/2024
Polyhydroxy-N,N-polyalkylbenzene-polycarboxamide	- -	7.5.1 Repeated dose toxicity: oral 7.8.2 Developmental toxicity / teratogenicity	27/05/2024
Sodium chlorite	231-836-6 7758-19-2	6.1.2 Long-term toxicity to fish 7.6.2 Genetic toxicity in vivo	28/06/2024
Tetramethylammonium hydroxide	200-882-9 75-59-2	7.8.2 Developmental toxicity / teratogenicity\|\|Note: testing proposed with Tetramethyl ammonium chloride (EC no. 200-880-8)	28/06/2024
Triisobutyl phosphate	204-798-3 126-71-6	6.1.2 Long-term toxicity to fish	27/05/2024

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Further Information

ECHA 1
ECHA 2

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Upcoming Approval for REACH Registration Testing Proposals for 12 Substances