SCCS Issued Preliminary Opinion on Benzophenone-1

On November 7, 2024, the Scientific Committee on Consumer Safety (SCCS) of the European Union issued a preliminary opinion on Benzophenone -1 (CAS No. 131-56-6). The deadline for comments on SCCS/1672/24 is set for January 13, 2025.

The SCCS concludes the following:

Having considered the data provided, and the concerns relating to the potential endocrine disrupting properties of Benzophenone-1 (BP-1), the SCCS cannot conclude on the safety of BP-1, because the information provided is insufficient to exclude genotoxicity.

The available evidence also shows that BP-1 is an endocrine-active substance due to clear demonstration of estrogenic activity and weak anti-androgenic activity both in vitro and in vivo, and potential activity against thyroid modality in vitro.

The Chinese Cosmetic Ingredient Regulatory Database (ChinaCosIng), independently developed by CIRS Group, indicates that Benzophenone -1, used as light stabilizer and UV absorber, has been included in the "Inventory of Existing Cosmetic Ingredients in China" (IECIC) (2021 edition) with the maximum historical usage in leave-on products being 0.936%.

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Further Information

Collection of SCCS's Opinion on Cosmetic Ingredients