%22 fill-rule=%22nonzero%22%3E%3Cpath d=%22M15.754367 31.4866226c-4.2011645.0-8.13699236-1.636243-11.14414171-4.5991696-6.14696705-6.146967-6.14696705-16.0970936.0-22.24406062C7.57315186 1.68046581 11.5532025.0442227846 15.754367.0442227846S23.8913594 1.68046581 26.8985087 4.64339238L21.6359973 9.90590374c-2.2995848-2.2995848-5.7489619-3.09559492-9.0656708-1.85735695C8.28071641 9.99434931 6.37913667 14.5492961 8.05960249 18.9715746c1.45935189 3.2282632 4.46650121 5.129843 7.73898731 5.129843 2.2111392.0 4.2896101-.8844557 5.8816303-2.4322532l5.2625114 5.2625114c-3.0071494 2.9187038-6.9872 4.5549468-11.1883645 4.5549468z%22 id=%22%E8%B7%AF%E5%BE%84%22 fill=%22%23001f60%22/%3E%3Cg id=%22%E7%BC%96%E7%BB%84%22 transform=%22translate(31.099673, 0.663342)%22%3E%3Cpolygon id=%22%E8%B7%AF%E5%BE%84%22 fill=%22%23001f60%22 points=%220 14.5050733 0 30.2041619 7.42942781 30.2041619 7.42942781 7.11986831%22/%3E%3Crect id=%22%E7%9F%A9%E5%BD%A2%22 fill=%22%2300bbb4%22 x=%220%22 y=%22-125688713e-22%22 width=%227.42942781%22 height=%227.11986831%22/%3E%3C/g%3E%3Cpath d=%22M99.6449893 19.0600201C98.1414146 13.6648404 92.525121 12.6919392 87.9701742 11.895929 87.5279463 11.8074835 87.0414957 11.7190379 86.5992679 11.6305923 83.5921185 11.0556961 83.3267818 10.878805 82.884554 10.6134683 82.0885438 10.0827949 82.0885438 9.06567084 82.4423261 8.49077464 83.0614451 7.47365059 84.6976881 6.89875439 86.6434907 6.89875439c4.0242733.0 5.2625113 1.7246886 5.4394025 2.74181264H99.7334349c0-2.43225315-1.4151291-4.95295187-3.75893670000001-6.76608603C94.2498096 1.54779746 91.2426602.0 86.5992679.0 81.4252021.0 78.4622755 1.94580252 76.914478 3.58204555 75.2340122 5.35095693 74.3495565 7.65054173 74.4380021 9.90590374 74.7033388 16.1855391 80.3638552 18.0428961 85.2725843 18.9273518 85.759035 19.0157974 86.2454856 19.1042429 86.7319362 19.1926885 87.9259514 19.4138024 89.4737489 19.6349163 90.7562096 20.0329214 91.5964425 20.2982581 92.4366754 21.0500455 92.0828932 22.2440606c-.2653368.8402329-1.6804659 1.9458026-4.2011646 2.1669165C85.2283615 24.632091 83.1056679 23.9687492 82.1327666 22.8631796 81.4694249 22.1556151 81.3809793 21.2711594 81.3809793 20.8289315H73.9515515C73.9515515 23.5707442 75.1013439 26.0914429 77.135592 27.9930226c2.3880303 2.2111393 5.8816303 3.4051544 9.6847898 3.4051544C87.3510552 31.398177 87.8817286 31.3539543 88.412402 31.3097315 92.8346805 30.9117264 96.3725033 29.142815 98.3183058 26.3567796 99.9545488 24.2783087 100.396777 21.6691644 99.6449893 19.0600201z%22 id=%22%E8%B7%AF%E5%BE%84%22 fill=%22%23001f60%22/%3E%3Cpath d=%22M71.6519667 30.8675036 63.7360882 20.2098125C67.9372528 19.0157974 70.9886249 15.2126379 70.9886249 10.6134683 70.9886249 5.12984301 66.5221237.663341768 61.0384984.663341768H44.8529592V30.8675036H52.282387V20.5635948h3.2282633l7.606319 10.3039088h8.5349974zM52.2381643 7.82743287h8.3581062c1.59202029999999.0 2.874481 1.28246075 2.874481 2.87448103.0 1.5920202-1.2824607 2.874481-2.874481 2.874481H52.2381643V7.82743287z%22 id=%22%E5%BD%A2%E7%8A%B6%22 fill=%22%23001f60%22/%3E%3C/g%3E%3C/g%3E%3C/svg%3E)
%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-34%22 transform=%22translate(1654.000000, 46.000000)%22%3E%3Cg id=%22%E7%9F%A9%E5%BD%A2%22 opacity=%22.01%22%3E%3Cuse fill=%22%23fff%22 xlink:href=%22%23path-1%22/%3E%3Cuse fill=%22%23f2f3f7%22 xlink:href=%22%23path-1%22/%3E%3C/g%3E%3Cg id=%22sousuo%22 transform=%22translate(6.000000, 6.000000)%22%3E%3Cmask id=%22mask-3%22 fill=%22%23fff%22%3E%3Cuse xlink:href=%22%23path-2%22/%3E%3C/mask%3E%3Cg id=%22Clip-2%22/%3E%3Cpath d=%22M11.6489827.0271704545c6.433526.0 11.6491213 5.1088636355 11.6491213 11.4108750455.0 2.9073068-1.110104 5.5606704-2.9376763 7.5756477C20.393341 19.0389886 20.424763 19.0662955 20.4543121 19.0953068l3.24437 3.1817727C24.099711 22.6703523 24.1004046 23.3084659 23.7004509 23.7025227L23.6986821 23.7042614C23.2966127 24.0985568 22.6454913 24.0985568 22.243422 23.7042614l-3.2445434-3.1817728C18.9553873 20.4797386 18.915815 20.433375 18.8807514 20.3838409L18.8809942 20.3841136c-1.986763 1.5431591-4.4995838 2.4646705-7.2320115 2.4646705C5.21545665 22.8487841.0 17.7400568.0 11.4380455.0 5.13603409 5.21545665.0271704545 11.6489827.0271704545zm0 2.0661136355c-5.26855495.0-9.53975727 4.18384091-9.53975727 9.34476141.0 5.1609204 4.27120232 9.344625 9.53975727 9.344625 5.2686936.0 9.5397225-4.1837046 9.5397225-9.344625.0-5.1609205-4.2710289-9.34476141-9.5397225-9.34476141z%22 id=%22Fill-1%22 fill=%22%23424242%22 mask=%22url(%23mask-3)%22/%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/svg%3E)
%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-8%22 transform=%22translate(1165.000000, 90.000000)%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-5%22 transform=%22translate(30.000000, 35.000000)%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-6%22 transform=%22translate(413.000000, 3.000000)%22%3E%3Cg id=%22sousuo%22 transform=%22translate(12.000000, 12.000000)%22%3E%3Cmask id=%22mask-2%22 fill=%22%23fff%22%3E%3Cuse xlink:href=%22%23path-1%22/%3E%3C/mask%3E%3Cg id=%22Clip-2%22/%3E%3Cpath d=%22M14.6489827 3.02717045c6.433526.0 11.6491213 5.10886364 11.6491213 11.41087505.0 2.9073068-1.110104 5.5606704-2.9376763 7.5756477C23.393341 22.0389886 23.424763 22.0662955 23.4543121 22.0953068l3.24437 3.1817727C27.099711 25.6703523 27.1004046 26.3084659 26.7004509 26.7025227L26.6986821 26.7042614C26.2966127 27.0985568 25.6454913 27.0985568 25.243422 26.7042614l-3.2445434-3.1817728C21.9553873 23.4797386 21.915815 23.433375 21.8807514 23.3838409L21.8809942 23.3841136c-1.986763 1.5431591-4.4995838 2.4646705-7.2320115 2.4646705C8.21545665 25.8487841 3 20.7400568 3 14.4380455 3 8.13603409 8.21545665 3.02717045 14.6489827 3.02717045zm0 2.06611364c-5.26855495.0-9.53975727 4.18384091-9.53975727 9.34476141.0 5.1609204 4.27120232 9.344625 9.53975727 9.344625 5.2686936.0 9.5397225-4.1837046 9.5397225-9.344625.0-5.1609205-4.2710289-9.34476141-9.5397225-9.34476141z%22 id=%22Fill-1%22 stroke=%22%23f2fbff%22 fill=%22%23f5f5f5%22 mask=%22url(%23mask-2)%22/%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/svg%3E)
%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-19%22 transform=%22translate(515.000000, 180.000000)%22%3E%3Crect id=%22%E7%9F%A9%E5%BD%A2%22 fill=%22%23fff%22 opacity=%22.2%22 x=%220%22 y=%220%22 width=%2280%22 height=%2280%22 rx=%2240%22/%3E%3Cg id=%22sousuo%22 opacity=%22.7%22 transform=%22translate(21.000000, 21.000000)%22%3E%3Cmask id=%22mask-2%22 fill=%22%23fff%22%3E%3Cuse xlink:href=%22%23path-1%22/%3E%3C/mask%3E%3Cg id=%22Clip-2%22/%3E%3Cpath d=%22M18.4442225.0430198864c10.1864162.0 18.4444422 8.0890340936 18.4444422 18.0672187136.0 4.6032358-1.7576647 8.8043949-4.6513208 11.9947756C32.2894566 30.1450653 32.3392081 30.1883011 32.3859942 30.2342358l5.1369191 5.0378068C38.1578757 35.8947244 38.158974 36.905071 37.5257139 37.5289943L37.5229133 37.5317472C36.8863035 38.1560483 35.8553613 38.1560483 35.2187514 37.5317472l-5.1371936-5.0378069C30.0126965 32.4262528 29.9500405 32.3528437 29.8945231 32.2744148L29.8949075 32.2748466C26.7491994 34.7181818 22.7705665 36.1772415 18.4442225 36.1772415 8.25780636 36.1772415.0 28.0884233.0 18.1102386.0 8.13205398 8.25780636.0430198864 18.4442225.0430198864zm0 3.2713465936c-8.3418786.0-15.10461556 6.62441477-15.10461556 14.79587212.0 8.1714574 6.76273696 14.7956563 15.10461556 14.7956563 8.3420983.0 15.1045607-6.6241989 15.1045607-14.7956563.0-8.17145735-6.7624624-14.79587212-15.1045607-14.79587212z%22 id=%22Fill-1%22 fill=%22%23000%22 mask=%22url(%23mask-2)%22/%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/svg%3E)
%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-11%22 transform=%22translate(625.000000, 180.000000)%22%3E%3Cg id=%22%E7%9F%A9%E5%BD%A2%22 opacity=%22.1%22%3E%3Cuse fill=%22%23fff%22 xlink:href=%22%23path-1%22/%3E%3Cuse fill=%22%23000%22 xlink:href=%22%23path-1%22/%3E%3C/g%3E%3Cg id=%22%E5%BD%A2%E7%8A%B6%E7%BB%93%E5%90%88-2%22 opacity=%22.9%22 transform=%22translate(23.000000, 23.000000)%22 fill=%22%23fff%22%3E%3Cpath d=%22M3.41421356.585786438 16.849 14.02 30.2842712.585786438C31.024212-.154154326 32.1996962-.193098576 32.9854836.468953686L33.1126984.585786438C33.893747 1.36683502 33.893747 2.63316498 33.1126984 3.41421356L19.677 16.849 33.1126984 30.2842712C33.893747 31.0653198 33.893747 32.3316498 33.1126984 33.1126984s-2.0473786.781048599999998-2.8284272.0L16.849 19.677 3.41421356 33.1126984C2.6742728 33.8526391 1.49878864 33.8915834.713001205 33.2295311L.585786438 33.1126984c-.781048584-.781048599999998-.781048584-2.0473786.0-2.8284272L14.02 16.849.585786438 3.41421356c-.781048584-.78104858-.781048584-2.04737854.0-2.828427122.781048582-.781048584 2.047378542-.781048584 2.828427122.0z%22 id=%22%E5%BD%A2%E7%8A%B6%E7%BB%93%E5%90%88%22/%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/svg%3E)
各有關單位：
為進一步規范和指導化妝品和原料的安全評價工作，根據《化妝品監督管理條例》《化妝品注冊備案管理辦法》等相關法規要求，我院制定了《化妝品原料急性吸入毒性試驗研究技術指導原則》等5項技術指導原則（見附件1—5）。按照《國家藥監局綜合司關于印發化妝品技術指導原則發布工作程序的通知》（藥監綜妝〔2022〕32號），現予發布。
特此通知。
中國食品藥品檢定研究院
2024年2月5日
中檢院關于印發《化妝品原料急性吸入毒性試驗研究技術指導原則》等5項技術指導原則的通知
來源 中檢院
掃描下方的二維碼訂閱“妝合規”！跟蹤化妝品最新產品安全與法規監管動態, 深入洞察化妝品研發與上市信息, 集萃行業大咖獨家觀點，獲得最新一手資訊。
① 凡本網注明"稿件來源：“杭州瑞旭科技集團有限公司"的所有文字、圖片和音視頻稿件，版權均屬杭州瑞旭科技集團有限公司所有，任何媒體、網站或個人未經本網協議授權不得轉載、鏈接、轉貼或以其他方式復制發表。已經本網協議授權的媒體、網站，在下載使用時必須注明"稿件來源：杭州瑞旭科技集團有限公司"，違者本網將依法追究責任。
② 本網未注明"稿件來源：杭州瑞旭科技集團有限公司 "的文/圖等稿件均為轉載稿，本網轉載出于傳遞更多信息之目的，并不意味著贊同其觀點或證實其內容的真實性。如其他媒體、網站或個人從本網下載使用，必須保留本網注明的"稿件來源"，并自負版權等法律責任。如擅自篡改為"稿件來源：杭州瑞旭科技集團有限公司"，本網將依法追究責任。如對稿件內容有疑議，請及時與我們聯系。
③ 如本網轉載稿涉及版權等問題，請作者在兩周內速來電或來函與杭州瑞旭科技集團有限公司聯系。
%22/%3E%3C/g%3E%3C/g%3E%3C/svg%3E)
%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-13%22 transform=%22translate(30.000000, 2950.000000)%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-3%22 transform=%22translate(15.000000, 950.000000)%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-27%22 transform=%22translate(40.000000, 215.000000)%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-10%22 transform=%22translate(0.000000, 144.000000)%22%3E%3Crect id=%22%E7%9F%A9%E5%BD%A2%22 fill=%22%23d8d8d8%22 opacity=%22.01%22 x=%220%22 y=%220%22 width=%2232%22 height=%2232%22/%3E%3Cg id=%22ios-call%22 opacity=%22.4%22 transform=%22translate(4.800000, 4.800000)%22%3E%3Cmask id=%22mask-2%22 fill=%22%23fff%22%3E%3Cuse xlink:href=%22%23path-1%22/%3E%3C/mask%3E%3Cg id=%22Clip-2%22/%3E%3Cpath d=%22M21.739546 17.5430608C20.882919 16.6863974 18.8257249 15.3985249 17.8117151 14.9147941 16.6345314 14.3495128 16.2032859 14.3611681 15.3699694 14.9614517c-.693453.5012501-1.1421814.9673158-1.9406413.7926322C12.631014 15.5850459 11.057587 14.3903428 9.53067187 12.8692553c-1.52676943-1.5267694-2.71564488-3.10019644-2.8846465-3.89865628-.16903805-.80414178.29720975-1.2470426.7924865-1.9406413C8.03875902 6.1966413 8.05627837 5.76539577 7.48516943 4.58821203 7.0014387 3.56837463 5.7193574 1.51704455 4.85690276.660381138 4.00023935-.196245854 3.80789073-.00972487805 3.33596098.159276748c0 0-.69942635.279726829-1.39287935.740001301C1.08641821 1.47049626.608515122 1.94829008.270621138 2.66505366c-.3322120323.7168-.7168 2.0513665 1.241214962 5.53626016C3.09109073 11.0161015 4.64135285 13.1489821 6.94323512 15.4451824L6.95489041 15.4568377c2.30188227 2.3019187 4.42893529 3.8519987 7.24372289 5.4312898 3.4849301 1.9581242 4.8194602 1.573427 5.5362602 1.2413606C20.4516735 21.7972397 20.9295766 21.3193366 21.5006855 20.456882 21.9610693 19.7634289 22.2407961 19.0641119 22.2407961 19.0641119 22.4098341 18.5920364 22.6020371 18.3996878 21.739546 17.5430608z%22 id=%22Fill-1%22 fill=%22%23000%22 mask=%22url(%23mask-2)%22/%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/svg%3E)
%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-13%22 transform=%22translate(30.000000, 2950.000000)%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-3%22 transform=%22translate(15.000000, 950.000000)%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-27%22 transform=%22translate(40.000000, 215.000000)%22%3E%3Cg id=%22%E7%BC%96%E7%BB%84-10%22 transform=%22translate(0.000000, 206.000000)%22%3E%3Crect id=%22%E7%9F%A9%E5%BD%A2%22 fill=%22%23d8d8d8%22 opacity=%22.01%22 x=%220%22 y=%220%22 width=%2232%22 height=%2232%22/%3E%3Cg id=%22ios-mail%22 opacity=%22.4%22 transform=%22translate(4.800000, 8.000000)%22 fill=%22%23000%22%3E%3Cpath d=%22M22.2035796 1.96720174 16.4132132 8.05344902C16.3701285 8.09790889 16.3701285 8.16447722 16.4132132 8.20893709l4.0521802 4.45365731c.274484099999999.2832104.274484099999999.738603.0 1.0216746C20.3308589 13.8230976 20.1478583 13.8953579 19.9703736 13.8953579 19.7927207 13.8953579 19.6097201 13.8230976 19.4751856 13.684269L15.4391495 9.24730586C15.3961994 9.20298482 15.3261742 9.20298482 15.2830559 9.24730586L14.298364 10.2802603c-.8233514.8607722-1.9158054 1.3382733-3.0889129 1.3438265C10.0201994 11.6296399 8.89004204 11.1132321 8.05592793 10.2413536L7.10877117 9.24730586C7.06568649 9.20298482 6.9957958 9.20298482 6.95271111 9.24730586L2.91667508 13.684269c-.13453454.1388286-.31743424.2110889-.49505346.2110889-.17761922.0-.36051892-.0722602999999999-.49505345-.2110889C1.65211772 13.4011974 1.65211772 12.9458048 1.92656817 12.6625944L5.97878198 8.20893709c.03756877-.044459869999999.03756877-.1110282.0-.155488069999999L.183000601 1.96720174C.112975375 1.89494143.0 1.94498915.0 2.04491106V14.2230629C0 15.2004165.774885285 16.0000347 1.72200841 16.0000347H20.6644372C21.611594 16.0000347 22.3866138 15.2004165 22.3866138 14.2230629V2.04491106C22.3866138 1.94498915 22.2680889 1.90052928 22.2035796 1.96720174z%22 id=%22Fill-1%22/%3E%3Cpath d=%22M11.1933069 10.1747852C11.9897177 10.1747852 12.7376961 9.85266811 13.2973598 9.264L21.7407135.395626898C21.4448721.15132321 21.0788372.00694143167 20.6752336.00694143167H1.71662703c-.40360361.0-.774885288.14438177833-1.065513516.38868546633L9.09446727 9.264C9.64878318 9.84711497 10.3968625 10.1747852 11.1933069 10.1747852z%22 id=%22Fill-2%22/%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/g%3E%3C/svg%3E)